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Are Proton Pump Inhibitors PPIs Safe?



GERD, heartburn, health, microbiome, gastrointestinal gi system, endoscopy by a gastroenterology doctor or gastroenterologist

What are some of the latest facts on proton pump inhibitors (PPIs) and long-term safety?


A recent, large placebo-controlled trial of 17,598 participants confirmed the safety of proton pump inhibitors (PPIs).


"Researchers find no evidence to support claims that proton pump inhibitors (PPIs) cause serious health issues such as pneumonia, chronic kidney disease, diabetes, and dementia."

Pantoprazole was not associated with any adverse event when used for 3 years, with the possible exception of an increased risk of enteric infections.


Thus, limiting prescriptions of PPI therapy because of concerns of long-term harm is not appropriate based on this study. However, this risk was lower than estimated by previous systematic reviews of observational studies.


Do Proton pump inhibitors (PPIs) cause serious health issues such as pneumonia, chronic kidney disease, diabetes, and dementia?


Researchers find no evidence to support claims that proton pump inhibitors (PPIs) cause serious health issues such as pneumonia, chronic kidney disease, diabetes, and dementia. This research is published in Gastroenterology, the official journal of the American Gastroenterological Association.


What are Proton pump inhibitors (PPIs)?


PPIs, such as exlansoprazole (Dexilant), esomeprazole (Nexium), lansoprazole (Prevacid), omeprazole (Prilosec), pantoprazole (Protonix), and rabeprazole (Aciphex) are medications that are effective in blocking gastric acid secretion.


GERD, heartburn, health, microbiome, gastrointestinal gi system, endoscopy by a gastroenterology doctor or gastroenterologist

PPIs are one of the most widely used drugs in the United States.


"GERD is one of the most common gastrointestinal disorders, with a prevalence of approximately 25% of adults in United States ."

What are Proton pump inhibitors (PPIs) used for?


PPIs are used for the treatment of peptic ulcer disease (PUD), gastroesophageal reflux disease (GERD), and much rarer conditions such as Zollinger-Ellison syndrome (ZES).


GERD occurs in over 25 percent of the population.


PPIs are also effective in the prevention of NSAID or nonsteroidal anti-inflammatory drug-associated gastroduodenal mucosal injury. NSAIDs are drugs such as ibuprofen and Advil.


PPIs plus antibiotics are used in the treatment of Helicobacter pylori infection.




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When should I take Proton pump inhibitors (PPIs)?


Ideally, oral PPIs should be administered 30 to 60 minutes before breakfast, or the first meal of the day. This provides for maximal acid suppression.


PPIs should not be administered at the same time with H2-receptor antagonists, such as Pepcid or Ranitidine if also being used.


For how long should I take Proton pump inhibitors (PPIs)?


PPIs should be prescribed at the lowest dose.


Like any medication, use for the shortest duration is appropriate.


These drugs are well tolerated in the short term.


Long-term treatment was associated with adverse events in observational studies.



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As with all drugs, PPI therapy should only be used when the benefits outweigh the risks. As with all drugs, PPI therapy should be used according to the recommended dose and duration of treatment.


What has been published about PPIs and associated side effects?

  • PPI use has been associated with an increased risk of Clostridium difficile infection. C. difficile infection with diarrhea may occur even in the absence of antibiotic use.

  • PPI use can lead to other enteric infections and microscopic colitis.

  • PPIs can cause hypomagnesemia due to reduced intestinal absorption.

  • Disrupting the stomach's delicate balance may cause changes in the immune system and trigger new allergies.

  • Long-term therapy with PPIs has been associated with vitamin B12 malabsorption.

  • Although an association between PPIs and bone fracture is plausible, direct causality has not been established.

  • PPIs can cause acute interstitial nephritis and chronic kidney disease (CKD), however further studies are needed.

  • The association between PPI use and dementia and pneumonia is not established and is conflicting. The same with an increased risk of death. Most likely is that these associations are due to the overall state of health of the patients, not the use of PPIs, and more studies are needed.

Here is a video called "Proton Pump Inhibitors Explained in 4 Minutes"


Tips on Proton Pump Inhibitors (PPIs)

  1. Talk to your doctor before making any changes. You have been prescribed PPIs for a reason. Probably to treat a diagnosed medical condition.

  2. Focus on lifestyle modifications for GERD. You may not need long-term use of PPIs or can reduce the dose. Read Heartburn, GERD, Acid Reflux—Are They Dangerous?

  3. Headlines on PPIs can be "scary" and hyped, but if PPIs are needed, and are treating a medical diagnosis, you should stay on them. Especially if the benefits outweigh the risks.



Tips en Español


Que son inhibidores de la bomba de protones (medicamentos) ?

Son medicamentos effectivos para mejorar problemas gastricos exlansoprazole (Dexilant), esomeprazole (Nexium), lansoprazole (Prevacid), omeprazole (Prilosec), pantoprazole (Protonix), and rabeprazole (Aciphex).


Es este medicamento seguro para consumir?

Scientificos no han encontrado evidencia que estas medicaciones causan pneumonia, enfermeda renal cronica ,diabetes, o demencia un estudio basado official de la Asociación Americana de Gastreologia. Este medicamento es para pacientes que sufrene reflujo gástrico, o enfermedad del reflujo gastroesofágico (ERGE).



Tips para este tipo de medicamento

  • Es un medicamento recetado por corto tiempo

  • Se consume 30-60 antes del desayuno

  • Consumir medicamento por largo tiempo puede causar enfermedades

  • Tener una condicion puede causar otras enfermedades

  • No consumir con otros medicamentos

  • Consulte con su doctor.


El 25 % de la poblacion en los Estados Unidos sufren de reflujo gástrico, o enfermedad del reflujo gastroesofágico (ERGE).


Summary


There is no magic formula for long-term, sustainable weight loss.


Balance. Portion control. Keep nutrition simple. Eat Smart. Eat Healthy. 🌱 🌾 🌿


Personally


I eat a high fiber, mostly plant-based 🌱 diet, no red meat, drink 4 liters of water a day, exercise, and am focused on keeping nutrition simple. I am sharing what works for me and what I routinely recommend to my patients.


"Balance. Portion control. Keep nutrition simple. Eat Smart. Eat Healthy. 🌱 🌾 🌿"

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Connect with Dr. Dooreck on LinkedIn where he focuses his sharing on Health, Diet, Nutrition, Exercise, Lifestyle, and Balance.


 

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